Lass J H, Campbell R C, Rose J, Foster C S, Dohlman C H
Arch Ophthalmol. 1981 Apr;99(4):673-6. doi: 10.1001/archopht.1981.03930010673014.
The effect of medroxyprogesterone acetate treatment in preventing or retarding corneal ulceration after alkali burns was studied in rabbits in an attempt to correlate dose and response. The eyes were treated for 21 days with a 0.01% or 1% suspension administered topically four times a day or medroxyprogesterone acetate, 4 mg or 30 mg, given subconjunctivally on alternate days. None of these regimens was noticeably effective, although at times there was a trend toward retarding ulceration. Thus, it was not possible to confirm earlier reports of substantial efficacy of medroxyprogesterone. Corneal stroma with epithelial defects and/or ulcers persistently showed infiltration with neutrophils in the superficial stroma within the epithelial defect, implicating the tears as the source of the inflammatory cells.
为了关联剂量与反应，在兔身上研究了醋酸甲羟孕酮治疗对预防或延缓碱烧伤后角膜溃疡形成的效果。眼睛用0.01%或1%的混悬液局部给药，每天4次，持续治疗21天，或者隔天结膜下注射4mg或30mg醋酸甲羟孕酮。尽管有时有延缓溃疡形成的趋势，但这些方案均未显示出明显效果。因此，无法证实早期关于醋酸甲羟孕酮具有显著疗效的报道。伴有上皮缺损和/或溃疡的角膜基质在上皮缺损内的浅层基质中持续显示有中性粒细胞浸润，提示泪液是炎症细胞的来源。
