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高压氧对清醒大鼠血脑屏障通透性无影响。

Lack of hyperbaric O2 effect on blood-brain barrier permeability in conscious rats.

作者信息

Gruenau S P, Folker M T, Rapoport S I

出版信息

Aviat Space Environ Med. 1981 Mar;52(3):162-5.

PMID:7225018
Abstract

Conscious rats were exposed to 100% O2 at 2.5 ATA for 90 min for up to 10 consecutive days, or to an N2-O2 mixture (PO2 = 0.3 ATA) under the same conditions (control animals). Cerebrovascular permeability to 14C-sucrose in the experimental animals was not altered by hyperbaric O2 exposure when compared to the value in control animals. These results differ with other reports that similar hyperbaric O2 exposure increases cerebrovascular permeability to ferritin and to a protein enzyme.

摘要

清醒大鼠连续10天每天在2.5个绝对大气压下暴露于100%氧气中90分钟,或在相同条件下暴露于氮气 - 氧气混合物(氧分压 = 0.3个绝对大气压)中(对照动物)。与对照动物相比,实验动物中脑血管对14C - 蔗糖的通透性在高压氧暴露后未发生改变。这些结果与其他报告不同,其他报告表明类似的高压氧暴露会增加脑血管对铁蛋白和一种蛋白酶的通透性。

相似文献

1
Lack of hyperbaric O2 effect on blood-brain barrier permeability in conscious rats.高压氧对清醒大鼠血脑屏障通透性无影响。
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2
Changes in the permeability of the blood-brain barrier under hyperbaric conditions.高压条件下血脑屏障通透性的变化。
Aviat Space Environ Med. 1978 Jul;49(7):890-4.
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Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen.一氧化氮合酶抑制对暴露于高压氧的麻醉大鼠脑氧合的影响
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Increased blood-brain permeability with hyperosmolar mannitol increases cerebral O2 consumption and O2 supply/consumption heterogeneity.高渗甘露醇导致的血脑通透性增加会使脑氧消耗增加,并使脑氧供应/消耗的异质性增加。
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Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increase.通过间歇性空气间歇延长大脑对高压氧的耐受性与脑血流量增加的时间有关。
Brain Res. 2006 Apr 21;1084(1):196-201. doi: 10.1016/j.brainres.2006.02.014. Epub 2006 Mar 20.
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Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation.在高压氧的辅助下,抗癌药物卡铂的跨内皮通透性增加。
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Subcutaneous tissue oxygen and carbon dioxide tensions during hyperbaric oxygenation: an experimental study in rats.高压氧疗期间皮下组织的氧分压和二氧化碳分压:大鼠实验研究
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Electromagnetic fields (1.8 GHz) increase the permeability to sucrose of the blood-brain barrier in vitro.电磁场(1.8吉赫兹)在体外会增加血脑屏障对蔗糖的通透性。
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引用本文的文献

1
Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier.血脑屏障经渗透修饰后将氨基己糖苷酶A输送至大脑。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5838-41. doi: 10.1073/pnas.78.9.5838.