Carpi R, Cordella M, Franchi A, Neri F
Ateneo Parmense Acta Biomed. 1980;51(5):445-51.
Chloroquine retinopathy is a drug disease that can be prevented. Among some suggested methods, fluorescence electroretinography allows an evaluation of drug retinal deposit. In fact if a fluorescent substance accumulates in the retinal cells, a very short wavelength stimulus can produce a bioelectric response. If soon detected drug absorption is reversible. Only in a long run, the drug can induce irreversible damages. Thus the importance of continuous control of the patients in treatment with chloroquine-drugs is necessary. In this study the results of an investigation of 38 patients treated with synthetic anit-malarial drugs are shown. In some subjects the presence of the drug in the retina, without anatomic lesions, was demonstrated. These deposits disappeared upon cessation of the treatment. Deposits with or without retinal lesions were noticed in 31% of the observed subjects. In these patients the suspension of drug administration reduced accumulation but did not influence retinal lesion shown by fluorangiography. The authors hypothesized that fluorescent substance deposit is made easier by retinal vasculopathy due to connective tissue disorders.
氯喹视网膜病变是一种可预防的药物性疾病。在一些建议的方法中，荧光视网膜电图可用于评估药物在视网膜的沉积情况。事实上，如果一种荧光物质在视网膜细胞中积累，一个非常短波长的刺激可以产生生物电反应。如果能很快检测到，药物吸收是可逆的。只有长期来看，药物才会导致不可逆转的损害。因此，对接受氯喹类药物治疗的患者进行持续监测非常重要。本研究展示了对38例接受合成抗疟药物治疗患者的调查结果。在一些受试者中，证实视网膜中有药物存在，但无解剖学病变。停止治疗后，这些沉积物消失。在31%的观察对象中发现了有或没有视网膜病变的沉积物。在这些患者中，停药减少了药物积累，但并未影响荧光血管造影显示的视网膜病变。作者推测，由于结缔组织疾病导致的视网膜血管病变使荧光物质更容易沉积。
