Labat P, Fauxpoint B, Carrica A, Rivaud C, Vedy J
Med Trop (Mars). 1979 May-Jun;39(3):307-13.
The use of overdoses of amino-4-quinoleines in non-malarial diseases has demonstrated various toxic actions on eyes. The most severe is retina lesion. Metabolism of these drugs and pathogeny of the lesions are discussed. With regard to aetiology, the main factor is overdose and duration of treatment. Clinical aspects are classified in three phases; the third one is divided in 5 stages. Treatment is only prophylactic.
在非疟疾疾病中过量使用4-氨基喹啉已显示出对眼睛的多种毒性作用。最严重的是视网膜病变。本文讨论了这些药物的代谢及病变的发病机制。关于病因，主要因素是用药过量和治疗持续时间。临床症状分为三个阶段；第三个阶段又分为5个分期。治疗仅为预防性的。
