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1
Labelled dyes, a new 125I-indomonocarbocyanine and 125I-BSP, in the exploration of experimental cholestasis and steatosis in the rat.标记染料，一种新型的125I-吲哚单碳菁染料和125I-溴磺酚酞，用于大鼠实验性胆汁淤积和脂肪变性的研究。
Br J Exp Pathol. 1981 Feb;62(1):13-21.
2
Preparation and metabolism of 125I-sulfobromophthalein.125I-磺溴酞的制备与代谢
Clin Chim Acta. 1983 Mar 14;128(2-3):321-7. doi: 10.1016/0009-8981(83)90331-5.
3
Opioid effects on hepatic disposition of dyes in mice.阿片类药物对小鼠肝脏中染料处置的影响。
J Pharmacol Exp Ther. 1985 Mar;232(3):617-23.
4
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.对两种肝脏细胞质有机阴离子结合蛋白Y和Z的研究：药物、化学物质、激素及胆汁淤积的影响
J Clin Invest. 1971 Nov;50(11):2242-52. doi: 10.1172/JCI106721.
5
The hepatic handling of 131I-labeled sulfobromophthalein in the dog. Comparison with sulfobromophthalein.狗体内131I标记的磺溴酞钠的肝脏处理。与磺溴酞钠的比较。
Biomedicine. 1976 Sep 30;25(7):255-8.
6
[A comparative study of the kinetics of 131I-bromsulphthalein and 125 I-biligrafin (author's transl)].
Wien Klin Wochenschr. 1976 Oct 15;88(19):627-30.
7
Comparison of sulfobromophthalein (BSP) and sulfobromophthalein glutathione (BSP-GSH) disposition under conditions of altered liver function and in the isolated perfused rat liver.肝功能改变条件下及在离体灌注大鼠肝脏中磺溴酞钠（BSP）与磺溴酞钠谷胱甘肽（BSP-GSH）处置情况的比较
J Lab Clin Med. 1976 Mar;87(3):373-83.
8
Sulfobromophthalein metabolism in isolated perfused rat liver. Factors determining the applicability of the model.离体灌注大鼠肝脏中磺溴酞的代谢。决定该模型适用性的因素。
Acta Physiol Lat Am. 1979;29(4-5):207-15.
9
[Distribution kinetics of 35S-BSP and 131-I-BR in subjects with healthy livers].[健康肝脏受试者中35S-磺溴酞钠和131-I-溴磺酚的分布动力学]
Z Gastroenterol. 1973 Jan;11(1):3-10.
10
The handling of bilirubin and sulfobromophthalein by the isolated perfused rat liver.离体灌注大鼠肝脏对胆红素和磺溴酞钠的处理
Acta Physiol Lat Am. 1979;29(4-5):217-22.

本文引用的文献

1
The radioactive (I131 tagged) rose bengal uptake-excretion test for liver function using external gamma-ray scintillation counting techniques.使用外部γ射线闪烁计数技术的放射性（I131标记）孟加拉玫瑰红摄取-排泄肝功能试验。
J Lab Clin Med. 1955 May;45(5):665-78.
2
The preparation and use of I-131 labeled sulfobromophthalein in liver function testing.
J Nucl Med. 1961 Oct;2:282-8.
3
Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction.吲哚菁绿：关于其物理性质、血浆衰变及肝脏摄取的观察
J Clin Invest. 1960 Apr;39(4):592-600. doi: 10.1172/JCI104072.
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Studies of hepatic function with indocyanine green.用吲哚菁绿进行的肝功能研究。
Gastroenterology. 1960 Dec;39:713-24.
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Indocyanine green: physical and physiologic properties.吲哚菁绿：物理和生理特性。
Proc Staff Meet Mayo Clin. 1960 Dec 7;35:732-44.
6
Blood disappearance of radioactive rose bengal; rapid simple test of liver function.放射性孟加拉玫瑰红的血液消失；肝功能快速简易检测
J Am Med Assoc. 1959 Jul 4;170(10):1159-64. doi: 10.1001/jama.1959.03010100021008.
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[Clinical studies on hepatic clearances].[肝脏清除率的临床研究]
Rev Int Hepatol. 1958;8(7):525-47.
8
Evaluation of the radioactive (I 131-tagged) rose bengal liver function test in nonjaundiced patients.非黄疸患者放射性（碘131标记）孟加拉玫瑰红肝功能试验的评估。
J Lab Clin Med. 1958 Dec;52(6):902-8.
9
Indocyanine green clearance as a test for hepatic function. Evaluation by dichromatic ear densitometry.吲哚菁绿清除率作为肝功能检测方法。双色耳密度测定法评估。
JAMA. 1967 Apr 17;200(3):236-40.
10
Preparation, properties and metabolism of iodinated bromosulphthalein.碘化溴磺酞的制备、性质及代谢
Nature. 1966 Aug 6;211(5049):645-6. doi: 10.1038/211645a0.

标记染料，一种新型的125I-吲哚单碳菁染料和125I-溴磺酚酞，用于大鼠实验性胆汁淤积和脂肪变性的研究。

Labelled dyes, a new 125I-indomonocarbocyanine and 125I-BSP, in the exploration of experimental cholestasis and steatosis in the rat.

作者信息

Lapalus F, Moreau M F, Meyniel G

出版信息

Br J Exp Pathol. 1981 Feb;62(1):13-21.

PMID:7225289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041635/
Abstract

A new dye, an indomonocarbocyanine labelled with radioactive iodine, was studied in normal rats and in rats with experimental diseases. After i.v. injection, the cyanine was selectively concentrated in the liver and eliminated in the bile; urinary excretion was found to be minimal but increased in rats with ligated bile duct. In addition, the blood clearance kinetics of the labelled dyes were significantly modified in cases of hepatic cholestasis or steatosis. A comparative study was carried out with 125I-BSP; the results showed that these 2 dyes may be considered as complementary in the exploration of liver function.

摘要

一种新的染料，一种用放射性碘标记的吲哚单碳菁染料，在正常大鼠和患有实验性疾病的大鼠身上进行了研究。静脉注射后，该菁染料选择性地集中在肝脏并经胆汁排出；发现尿液排泄极少，但在胆管结扎的大鼠中有所增加。此外，在肝内胆汁淤积或脂肪变性的情况下，标记染料的血液清除动力学有显著改变。用125I-磺溴酞钠进行了一项对比研究；结果表明，这两种染料在肝功能检查中可被视为互补。