标记染料，一种新型的125I-吲哚单碳菁染料和125I-溴磺酚酞，用于大鼠实验性胆汁淤积和脂肪变性的研究。
Labelled dyes, a new 125I-indomonocarbocyanine and 125I-BSP, in the exploration of experimental cholestasis and steatosis in the rat.
作者信息
Lapalus F, Moreau M F, Meyniel G
出版信息
Br J Exp Pathol. 1981 Feb;62(1):13-21.
A new dye, an indomonocarbocyanine labelled with radioactive iodine, was studied in normal rats and in rats with experimental diseases. After i.v. injection, the cyanine was selectively concentrated in the liver and eliminated in the bile; urinary excretion was found to be minimal but increased in rats with ligated bile duct. In addition, the blood clearance kinetics of the labelled dyes were significantly modified in cases of hepatic cholestasis or steatosis. A comparative study was carried out with 125I-BSP; the results showed that these 2 dyes may be considered as complementary in the exploration of liver function.
一种新的染料，一种用放射性碘标记的吲哚单碳菁染料，在正常大鼠和患有实验性疾病的大鼠身上进行了研究。静脉注射后，该菁染料选择性地集中在肝脏并经胆汁排出；发现尿液排泄极少，但在胆管结扎的大鼠中有所增加。此外，在肝内胆汁淤积或脂肪变性的情况下，标记染料的血液清除动力学有显著改变。用125I-磺溴酞钠进行了一项对比研究；结果表明，这两种染料在肝功能检查中可被视为互补。
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