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[脑苷脂和磷脂 - 脑苷脂膜的某些物理参数]

[Certain physical parameters of cerebroside and phospholipid-cerebroside membranes].

作者信息

Mkheian E E, Akopov S E, Sotskiĭ O P, Badzhinian S A

出版信息

Biofizika. 1981 Jan-Feb;26(1):48-52.

PMID:7225449
Abstract

Study of some electric properties of bilayer membranes made of cerebrosides and phospholipid-cerebroside mixture has shown that the capacity of cerebroside film is lower than that of lecithin-cerebroside and phospholipid-cerebroside ones (0.22 +/- 0.01 mkf/cm2 and 0.28 +/- 0.01 mkf/cm2 respectively). The membranes had small cation selectivity. It is stated that conductivity of cations of mixed phospholipid-cerebroside membrane is two orders, and of cerebroside three orders higher than that of phospholipid bilayers. Conductivity of the films under study depends on the medium pH. By means of fluorescent probes cerebrosides were found capable of changing the conformation of phospholipid membranes.

摘要

对由脑苷脂和磷脂 - 脑苷脂混合物制成的双层膜的一些电学性质的研究表明,脑苷脂膜的电容低于卵磷脂 - 脑苷脂膜和磷脂 - 脑苷脂膜(分别为0.22±0.01微法/平方厘米和0.28±0.01微法/平方厘米)。这些膜具有较小的阳离子选择性。据指出,混合磷脂 - 脑苷脂膜的阳离子电导率比磷脂双层膜高两个数量级,而脑苷脂膜的阳离子电导率比磷脂双层膜高三 个数量级。所研究薄膜的电导率取决于介质的pH值。通过荧光探针发现脑苷脂能够改变磷脂膜的构象。

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