Canal P, Bugat R, Soula G, Combes P F
Biomedicine. 1980 Nov;33(7):222-6.
The routine practice of making enzymatic assessments for the purposes of cancer diagnosis, including the determination of total amount of LDH provides only limited information. However, the total amount of LDH may be used to monitor the effect of chemotherapy or radiotherapy in certain tumours, such as epithelial tumours and germ-cell tumours of the ovaries, non Hodgkin's lymphomas or malignant tumours of the testicles. The differentiation of LDH isoenzymes, with a view to linking their pattern to precise localizations has been studied. In germ-cell testicular tumours, there is a marked increase in LDH 1. In liver metastases, LDH 5 and/or LDH 4 are disturbed in 90% of the cases, while the total amount of LDH is raised in only 72% of the cases. In many cases, the association of a disturbance in the serum ratio of the total amount of LDH and a disturbance in the isoenzymes of LDH 4 and LDH 5 associated with a high level of GGT indicate the presence of liver metastases.
为癌症诊断目的进行酶学评估的常规做法，包括测定乳酸脱氢酶（LDH）的总量，所提供的信息有限。然而，LDH总量可用于监测某些肿瘤（如卵巢上皮肿瘤和生殖细胞肿瘤、非霍奇金淋巴瘤或睾丸恶性肿瘤）的化疗或放疗效果。人们已经研究了LDH同工酶的分化情况，以期将其模式与精确的定位联系起来。在睾丸生殖细胞肿瘤中，LDH 1显著增加。在肝转移瘤中，90%的病例中LDH 5和/或LDH 4出现异常，而只有72%的病例中LDH总量升高。在许多情况下，血清中LDH总量比例异常与LDH 4和LDH 5同工酶异常同时出现，且γ-谷氨酰转移酶（GGT）水平升高，提示存在肝转移。
