[吡唑醇对A型单胺氧化酶的选择性抑制作用]
[Selective inhibition of type A monoamine oxidase by pyrazidol].
作者信息
Mashkovskiĭ M D, Gorkin V Z, Verevkina I V, Asnina V V, Tupikina S M
出版信息
Biull Eksp Biol Med. 1981 Feb;91(2):169-71.
PMID:7225552
Abstract
Effect of a new antidepressant pyrazidol (1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino /1,2-/ indole) on the liver and brain MAO activity of rats was studied in experiments in vivo and in vitro. Pyrazidol selectively blocks type A MAO (the substrates serotonin and noradrenaline) and does not virtually affect or has a far less action on type B MAO (the substrate 2-phenylethylamine).
摘要
在体内和体外实验中研究了一种新型抗抑郁药吡唑醇（1,10-亚甲基-8-甲基-1,2,3,4-四氢吡嗪并/1,2-/吲哚）对大鼠肝脏和大脑单胺氧化酶（MAO）活性的影响。吡唑醇选择性阻断A型MAO（底物为5-羟色胺和去甲肾上腺素），而实际上对B型MAO（底物为2-苯乙胺）没有影响或影响极小。
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