Skoff R, Montgomery I N
Brain Res. 1981 May 11;212(1):175-81. doi: 10.1016/0006-8993(81)90047-0.
The Jimpy mouse is a sex-linked neurological mutant characterized by a paucity of myelin in the central nervous system (CNS). The distribution of myelin in the optic nerves of female carriers of the Jimpy gene exhibits a mosaic pattern such that patches of tissue along the nerve are identical in appearance to the hemizygote male, while other areas appear normal.
Jimpy 小鼠是一种性连锁神经突变体,其特征是中枢神经系统(CNS)中髓磷脂缺乏。Jimpy 基因雌性携带者视神经中的髓磷脂分布呈现出镶嵌模式,即沿神经的组织斑块在外观上与半合子雄性相同,而其他区域看起来正常。