在携带Jimpy基因杂合子的雌性小鼠中嵌合体的表达。
Expression of mosaicism in females heterozygous for Jimpy.
作者信息
Skoff R, Montgomery I N
出版信息
Brain Res. 1981 May 11;212(1):175-81. doi: 10.1016/0006-8993(81)90047-0.
PMID:7225855
Abstract
The Jimpy mouse is a sex-linked neurological mutant characterized by a paucity of myelin in the central nervous system (CNS). The distribution of myelin in the optic nerves of female carriers of the Jimpy gene exhibits a mosaic pattern such that patches of tissue along the nerve are identical in appearance to the hemizygote male, while other areas appear normal.
摘要
Jimpy 小鼠是一种性连锁神经突变体，其特征是中枢神经系统（CNS）中髓磷脂缺乏。Jimpy 基因雌性携带者视神经中的髓磷脂分布呈现出镶嵌模式，即沿神经的组织斑块在外观上与半合子雄性相同，而其他区域看起来正常。
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