向下丘脑核内注射前列腺素F2α后的心血管及交感神经反应。

Cardiovascular and sympathetic responses to PGF2 alpha injection into hypothalamic nuclei.

作者信息

Feuerstein G, Adelberg S A, Kopin I J, Jacobowitz D M

出版信息

Brain Res Bull. 1981 Mar;6(3):203-7. doi: 10.1016/s0361-9230(81)80048-2.

Abstract

Injection of prostaglandin F2 alpha (1 nmol/rat) into the paraventricular, dorsomedial and posterior hypothalamic nuclei of halothane anesthetized rats elicited rapid increases of heart rate and blood pressure. The injection of this same dose of prostaglandin F2 alpha into the cerebroventricular system or intravenously had no effect on these parameters. The cardiovascular responses observed following prostaglandin F2 alpha injection into these hypothalamic nuclei were accompanied by increases in plasma levels of norepinephrine and epinephrine, with peak levels at the maximal cardiovascular response. This study suggests a possible role for prostaglandin F2 alpha in modulation of the cardiovascular system via specific hypothalamic nuclei.

摘要

将前列腺素F2α（1纳摩尔/大鼠）注射到氟烷麻醉大鼠的室旁核、背内侧核和下丘脑后核中，可使心率和血压迅速升高。将相同剂量的前列腺素F2α注射到脑室系统或静脉内对这些参数没有影响。在将前列腺素F2α注射到这些下丘脑核后观察到的心血管反应伴随着去甲肾上腺素和肾上腺素血浆水平的升高，在最大心血管反应时达到峰值水平。这项研究表明前列腺素F2α可能通过特定的下丘脑核在心血管系统调节中发挥作用。