Cardiovascular effects of intrahypothalamic injections of alpha-melanocyte stimulating hormone.

Injection of alpha-melanocyte stimulating hormone (alpha-MSH, 0.6-1.2 nmol in 100-300 nl) into the rostral dorsomedial hypothalamic nucleus of the halothane anesthetized rat resulted in a 12% increase in heart rate (41 +/- 4 bpm) which was accompanied by a slight increase in blood pressure (5 +/- 1 mm Hg). The response was characterized by a gradual onset, with a peak increase at 7 +/- 1 min and a duration of 51 +/- 6 min. Tachyphylaxis to the response was apparent for at least 180 min following initial exposure to the peptide. In contrast to the increase in heart rate observed following alpha-MSH injection into the dorsomedial nucleus, injections into the medial preoptic, anterior, paraventricular or posterior hypothalamic nuclei had no significant effects on blood pressure and heart rate. These data suggest a possible role for brain alpha-MSH in the central control of heart rate at a site within the dorsomedial nucleus of the hypothalamus.