Feindel C M, Harper R, Wallace A C, Wall W J
Can J Surg. 1981 Mar;24(2):147-9, 151.
The experiments described in this study challenge the 20th century belief that the liver is particularly vulnerable to deprivation of its blood supply for appreciable periods of time. The authors studied the effects of 60 minutes of normothermic hepatic ischemia on 10 pigs. The hepatic artery and its collateral vessels were occluded and portal blood was diverted by a portojugular shunt. This produced a 90% reduction in liver blood flow as determined by xenon-127 washout. None of the animals died of liver failure. The ischemic insult did not produce jaundice in any of the animals and only minimal transient changes in liver enzymes occurred. The results suggest that the liver is capable of withstanding prolonged periods of ischemia.
本研究中所描述的实验对20世纪的一种观点提出了挑战，即肝脏在相当长的一段时间内特别容易因血液供应中断而受损。作者对10头猪进行了60分钟常温下肝脏缺血的影响研究。肝动脉及其侧支血管被阻断，门静脉血通过门颈静脉分流术改道。通过氙-127洗脱测定，这使得肝脏血流减少了90%。没有一只动物死于肝功能衰竭。缺血损伤在任何一只动物中都没有导致黄疸，并且仅出现了肝脏酶的轻微短暂变化。结果表明肝脏能够耐受长时间的缺血。
