Mullins J D, Hilliard G D
Cancer. 1981 Feb 15;47(4):785-90. doi: 10.1002/1097-0142(19810215)47:4<785::aid-cncr2820470425>3.0.co;2-z.
On microscopic examination of a cervical carcinoid removed from a 29-year-old woman, foci of endocervical adenocarcinoma in situ (AIS) and severe squamous dysplasia were present immediately adjacent to the invasive carcinoid tumor. Cells of the carcinoid tumor contained abundant intracytoplasmic argyrophilic granules and numerous neurosecretory granules (NSG) on ultrastructural study. Neoplastic cells of the endocervical AIS were devoid of argyrophilic granules and contained no NSGs. The present neoplastic process appeared similar to cases of a "mixed" type neoplasm composed of a carcinoid tumor and an adenocarcinoma, which have been reported from several areas of the body but only once previously from the cervix. The possible mechanisms accounting for such an unusual neoplastic process are discussed.
在对一名29岁女性切除的宫颈类癌进行显微镜检查时，在侵袭性类癌肿瘤紧邻处发现了宫颈管原位腺癌（AIS）灶和重度鳞状上皮发育异常。在超微结构研究中，类癌肿瘤细胞含有丰富的胞质嗜银颗粒和大量神经分泌颗粒（NSG）。宫颈管AIS的肿瘤细胞缺乏嗜银颗粒且不含NSG。目前的肿瘤形成过程似乎类似于由类癌肿瘤和腺癌组成的“混合”型肿瘤病例，此类病例在身体的多个部位都有报道，但此前仅在宫颈有过一次报道。本文讨论了导致这种不寻常肿瘤形成过程的可能机制。
