Albores-Saavedra J, Larraza O, Poucell S, Rodríguez Martínez H A
Cancer. 1976 Dec;38(6):2328-42. doi: 10.1002/1097-0142(197612)38:6<2328::aid-cncr2820380620>3.0.co;2-j.
Twelve carcinoid tumors of the uterine cervix were studied. Based on the microscopic structure, they were divided into well-differentiated and poorly differentiated types. Both tumor varieties affected adult women. The clinical and gross features of these tumors were indistinguishable from those of invasive squamous cell carcinoma. Of the 12 patients, six died, four with poorly differentiated carcinoid and two with the well-differentiated type. Three patients are alive and symptom-free 9 months to 2 years after treatment; the remaining three were lost to follow-up. Microscopically, four well-differentiated carcinoids showed argyrophil cells, and ultrastructurally two had neurosecretory granules. One of the well-differentiated carcinoids resembled islet cell carcinoma and two had areas resembling medullary carcinoma of the thyroid. The poorly differentiated type of carcinoid had a histologic structure and a cell population very similar to that of the oat cell carcinoma of the lung. Of this group, four were argyrophilic, and by electron microscopy four contained pleomorphic secretory granules. It is considered that these tumors arise from the normal argyrophil cell of the cervix and are part of the group of neoplasms of the diffuse endocrine cell system (APUD).
对12例子宫颈类癌肿瘤进行了研究。根据微观结构，它们被分为高分化型和低分化型。这两种肿瘤类型均累及成年女性。这些肿瘤的临床和大体特征与浸润性鳞状细胞癌难以区分。12例患者中，6例死亡，4例为低分化类癌，2例为高分化型。3例患者在治疗后9个月至2年存活且无症状；其余3例失访。显微镜下，4例高分化类癌显示嗜银细胞，超微结构上2例有神经分泌颗粒。其中1例高分化类癌类似胰岛细胞癌，2例有类似甲状腺髓样癌的区域。低分化型类癌的组织结构和细胞群体与肺燕麦细胞癌非常相似。该组中，4例为嗜银性，电子显微镜检查显示4例含有多形性分泌颗粒。认为这些肿瘤起源于宫颈正常嗜银细胞，是弥漫性内分泌细胞系统（APUD）肿瘤组的一部分。
