Ho C S, McLoughlin M J, Tao L C, Blendis L, Evans W K
Cancer. 1981 Apr 1;47(7):1781-5. doi: 10.1002/1097-0142(19810401)47:7<1781::aid-cncr2820470710>3.0.co;2-q.
Forty patients with suspected malignant disease of the liver underwent percutaneous fine-needle aspiration biopsy with radioisotope scintigraphic and fluoroscopic guidance. The needle was aimed at focal defects identified on the liver scan and several passes were made. When the scan was diffusely abnormal, the liver was widely sampled with multiple passes. Thirty patients were eventually considered to have malignant disease and aspiration biopsy was positive in 28 (93%) of these patients, including 25 of 26 with liver metastases (96%). There were two false-positive results and one minor complication. In 24 patients, conventional wide-bore needle biopsy was also performed. In this group, 16 patients had a final diagnosis of hepatic malignancy. Aspiration biopsies were positive in 14 of these (87%) and conventional needle biopsies were positive in four (25%). Guided percutaneous fine-needle aspiration biopsy is recommended for pathologic diagnosis of hepatic malignancy because of its simplicity, high yield, and reasonable safety.
40例疑似肝脏恶性疾病的患者在放射性核素闪烁扫描和荧光镜引导下接受了经皮细针穿刺活检。穿刺针指向肝脏扫描中发现的局灶性缺损部位，并进行多次穿刺。当扫描显示弥漫性异常时，则对肝脏进行广泛多点穿刺取样。最终30例患者被确诊患有恶性疾病，其中28例（93%）穿刺活检结果呈阳性，包括26例肝转移患者中的25例（96%）。有2例假阳性结果和1例轻微并发症。24例患者还接受了传统的粗针活检。在这组患者中，16例最终被诊断为肝脏恶性肿瘤。其中14例（87%）细针穿刺活检呈阳性，4例（25%）粗针活检呈阳性。鉴于其操作简单、阳性率高且安全性合理，推荐采用引导下经皮细针穿刺活检来进行肝脏恶性肿瘤的病理诊断。
