Pallesen G
Cancer. 1981 Apr 1;47(7):1834-7. doi: 10.1002/1097-0142(19810401)47:7<1834::aid-cncr2820470719>3.0.co;2-t.
A case of a highly differentiated, primary, nonurachal adenocarcinoma of intestinal type, originating from the urinary bladder mucosa, is reported. The tumor contained Paneth cells as an integrated part, and their identity on the light microscopic level was confirmed by histochemical stains including immunohistochemical stain for muramidase. A gradual change from Paneth cell types to mucous cells was seen. Argentaffin cells and goblet cells appeared in some parts of the tumor but no detectable transitional forms were found. Only a few carcinomas containing malignant Paneth cells have been recorded, and this case is believed to be the first observed in an extraintestinal site.
本文报道了一例起源于膀胱黏膜的高分化原发性肠型非脐尿管腺癌。肿瘤包含潘氏细胞作为其组成部分，通过组织化学染色（包括溶菌酶免疫组化染色）在光镜水平证实了其特征。可见从潘氏细胞类型逐渐向黏液细胞的转变。嗜银细胞和杯状细胞出现在肿瘤的某些部位，但未发现可检测到的过渡形式。仅有少数含有恶性潘氏细胞的癌被记录，本病例被认为是在肠外部位首次观察到的。
