Lev R, Grover R
Cancer. 1981 Apr 15;47(8):2007-15. doi: 10.1002/1097-0142(19810415)47:8<2007::aid-cncr2820470818>3.0.co;2-w.
All polyps and strips of colonic mucosa 1 to 15 cm from tumor margins were examined for possible precursors of carcinoma in 24 patients undergoing partial colectomy for primary colorectal adenocarcinoma. Of 114 polyps found, 40.4% were adenomatous, and the remainder were hyperplastic or inflammatory or showed normal mucosa. No primarily dysplastic lesions, which could be interpreted as early de novo carcinomas, were found. Serial sections of mucosal strips revealed minute adenomatous foci in 3 of 24 patients, one of whom also showed several patches of exclusively dysplastic epithelium. This finding suggest that carcinoma may rarely arise de novo, but most carcinomas appear to be accompanied by (? preceded by) adenomatous changes.
对24例因原发性结直肠癌接受部分结肠切除术的患者，检查了距肿瘤边缘1至15厘米的所有结肠息肉和结肠黏膜条带，以寻找可能的癌前病变。在发现的114个息肉中，40.4%为腺瘤性，其余为增生性、炎性或显示正常黏膜。未发现可解释为早期新发癌的原发性发育异常病变。黏膜条带的连续切片在24例患者中的3例中发现了微小腺瘤灶，其中1例还显示有几处单纯发育异常上皮斑。这一发现表明，癌很少新发产生，但大多数癌似乎伴有（？先于）腺瘤性改变。
