用色氨酸产物处理诱导中国仓鼠肺细胞产生对8-氮鸟嘌呤或哇巴因耐药的体细胞突变。
Induction of 8-azaguanine or ouabain resistant somatic mutation of Chinese hamster lung cells by treatment with tryptophan products.
作者信息
Inui N, Nishi Y, Hasegawa M M, Kawachi T
出版信息
Cancer Lett. 1980 May;9(3):185-9. doi: 10.1016/0304-3835(80)90085-3.
The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fold higher mutagenicity than DEN when mutants were selected with ouabain. From these findings, it is suggested that pyrolyzates of amino acids may have mutagenic actions on somatic cells of animals, as well as carcinogenic actions.
色氨酸热解产物的基本组分（TBF）对中国仓鼠肺体细胞表现出很强的诱变活性。在这项体细胞突变试验中，当用8-氮杂鸟嘌呤筛选突变体时，TBF的诱变性比二乙基亚硝胺（DEN）高5.6倍，而当用哇巴因筛选突变体时，其诱变性比DEN高13.5倍。从这些发现可以推测，氨基酸热解产物可能对动物体细胞具有诱变作用，以及致癌作用。
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