Luzzatto A C
Cell Tissue Res. 1981;215(1):133-42. doi: 10.1007/BF00236254.
Rat hepatocyte differentiation between day 12 and 19 of fetal life was studied by electron microscopy. The cytoplasmic structures involved in synthetic and secretory function, i.e., rough endoplasmic reticulum and Golgi apparatus, appear to be the first to differentiate, and their development is probably related to the secretion of different kinds of plasma proteins. The cytoplasmic organelles involved in other hepatic functions develop later: lysosomes from day 15, peroxysomes, glycogen rosettes and smooth endoplasmic reticulum still later. However, the morphological differentiation of bile canaliculi begins from day 12.
通过电子显微镜研究了胎龄12至19天大鼠肝细胞的分化情况。参与合成和分泌功能的细胞质结构，即粗面内质网和高尔基体，似乎是最先分化的，它们的发育可能与不同种类血浆蛋白的分泌有关。参与其他肝脏功能的细胞质细胞器发育较晚：溶酶体从第15天开始，过氧化物酶体、糖原玫瑰花结和平滑内质网更晚。然而，胆小管的形态分化从第12天开始。
