一种用于定量测定人血清中氯美噻唑的快速气相色谱法。

A rapid gas-chromatographic method for the quantitative determination of clomethiazole in human serum.

作者信息

Heipertz R, Reimer C

出版信息

Clin Chim Acta. 1981 Mar 5;110(2-3):131-8. doi: 10.1016/0009-8981(81)90342-9.

Abstract

A rapid method without elaborate instrumentation for the determination of clomethiazole serum concentrations is described. This method is suitable for a routine clinical laboratory, and the results, from 37 patients investigated by this method which are presented, are comparable to results described by other authors. A relationship between dose ingested and serum concentration can be established. The determination of clomethiazole serum concentrations is useful as an adjunct to overall clinical assessment, and helpful in establishing a suitable dosage regimen of clomethiazole for the individual patient; it can also be used to verify suspected clomethiazole abuse or overdose.

摘要

本文描述了一种无需复杂仪器即可快速测定氯美噻唑血清浓度的方法。该方法适用于常规临床实验室，文中给出的用此方法对37例患者进行检测的结果，与其他作者描述的结果具有可比性。可以确定摄入剂量与血清浓度之间的关系。测定氯美噻唑血清浓度有助于全面的临床评估，有助于为个体患者确定合适的氯美噻唑给药方案；它还可用于核实氯美噻唑滥用或过量的疑似情况。