Heinemann F, Assion H J
Department of Neurology, St-Josef-Hospital, Moers, Germany.
Pharmacopsychiatry. 1996 Sep;29(5):196-7. doi: 10.1055/s-2007-979571.
We report on a patient with a history of alcoholism who developed hyperbilirubinemia induced by treatment with clomethiazole during two hospitalizations. After discontinuation of clomethiazole symptoms of cholestasis improved. Clomethiazole is a thiazole analogon and is chemically related to thiamine (vitamin B1). It can be administered as tablets, capsules, mixtures, and a 0.8% solution. Because of its sedative, hypnotic, and anti-convulsive effects it is used in the treatment of alcoholic delirium.
我们报告了一名有酗酒史的患者，该患者在两次住院期间因使用氯美噻唑治疗而出现高胆红素血症。停用氯美噻唑后，胆汁淤积症状有所改善。氯美噻唑是一种噻唑类似物，在化学上与硫胺素（维生素B1）相关。它可以制成片剂、胶囊、合剂和0.8%的溶液剂型。由于其具有镇静、催眠和抗惊厥作用，它被用于治疗酒精性谵妄。
