Rawlings N C, Pant H C, Ward W R
J Reprod Fertil. 1978 Nov;54(2):363-7. doi: 10.1530/jrf.0.0540363.
Six ewes were treated twice daily with intravenous injections of antiserum to oestrogens and 3 ewes received normal sheep serum from Day 140 of gestation until parturition. All 9 ewes experienced normal parturitions and produced healthy active lambs after similar gestation lengths. Progesterone and prostaglandin F concentrations in maternal jugular venous plasma were similar in the immunized and control ewes, but total unconjugated oestrogen concentrations were significantly higher in the immunized ewes (P less than 0.005). It is concluded that immunization of the ewe against total unconjugated oestrogens did not affect the normal occurrence of parturition.
六只母羊从妊娠第140天起每天接受两次静脉注射雌激素抗血清，三只母羊在妊娠第140天至分娩期间接受正常绵羊血清。所有九只母羊都正常分娩，且在相似的妊娠期后产下健康活泼的羔羊。免疫母羊和对照母羊的母羊颈静脉血浆中孕酮和前列腺素F浓度相似，但免疫母羊中总未结合雌激素浓度显著更高（P小于0.005）。得出的结论是，母羊针对总未结合雌激素进行免疫不会影响分娩的正常发生。
