Chuang C Y, Chen W Y, Yen T S, Hsieh B S, Lee C S, Luo S F, Lin K T, Chen C Y
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1980 Dec;13(4):376-85.
Simultaneous studies of serum and urinary proteins in 294 adult proteinuric patients are presented. Our data showed that these studies can provide valuable guides for clinical diagnosis. In the group of idiopathic nephrotic syndrome, hypoalbuminemia, hypogammaglobulinemia and hyper-alpha 2 globulinemia were most marked. Urinary protein electrophoresis (PEP) showed a well-selective pattern with albumin and beta globulin as the main constituents. In the other groups of proteinuric patients the hypoalbuminemia and hyper-alpha 2 globulinemia were milder and urinary PEP generally showed non-selective pattern. In the groups of acute glomerulonephritis and lupus nephropathy, C3 was generally decreased; polyclonal gammopathy was frequently encountered and alpha 1 acid glycoprotein was markedly increased. In the cases of chronic glomerulonephritis and diabetic nephropathy and the levels of gamma globulin, C3 and alpha 2 acid glycoprotein were usually within normal limits. Urinary protein selectivity index in this series of adult patients was not a useful diagnostic parameter.
本文呈现了对294例成年蛋白尿患者血清和尿液蛋白质的同步研究。我们的数据表明，这些研究可为临床诊断提供有价值的指导。在特发性肾病综合征组中，低白蛋白血症、低丙种球蛋白血症和高α2球蛋白血症最为明显。尿蛋白电泳（PEP）显示出以白蛋白和β球蛋白为主要成分的高度选择性模式。在其他蛋白尿患者组中，低白蛋白血症和高α2球蛋白血症较轻，尿PEP通常显示非选择性模式。在急性肾小球肾炎和狼疮性肾病组中，C3通常降低；多克隆丙种球蛋白病经常出现，α1酸性糖蛋白明显增加。在慢性肾小球肾炎和糖尿病肾病病例中，γ球蛋白、C3和α2酸性糖蛋白水平通常在正常范围内。这一系列成年患者的尿蛋白选择性指数并非有用的诊断参数。
