儿童各种肾脏疾病中蛋白尿的电泳图谱。

Electrophoresis patterns of proteinuria in various renal diseases of childhood.

作者信息

Zajaczkowska Małgorzata, Borzecka Halina, Zinkiewicz Zofia, Biaduń Urszula

机构信息

Department of Pediatric Nephrology, Medical University of Lublin.

出版信息

Ann Univ Mariae Curie Sklodowska Med. 2003;58(1):362-6.

PMID:15315016

Abstract

The purpose of the study was to assess electrophoresis patterns of proteinuria in children with different renal diseases. The study comprised 52 children (30 boys and 22 girls) aged 2-18 years hospitalized in the Department of Nephrology, University Children's Hospital, Lublin. Nephrotic syndrome, glomerulonephritis and isolated proteinuria were diagnosed in 26, 11 and 15 children, respectively. Electrophoresis of urinary proteins was performed using the system SEBIA-Hydragel Proteinuria. Steroid-responsive, steroid-resistant and steroid-dependent nephrotic syndromes were characterized by glomerular selective proteinuria in 76%, 40% and 12.5% of children, respectively. In other nephrotic children glomerular nonselective proteinuria was identified. Selective glomerular proteinuria was found in 45.5% of children with glomerulonephritis. In this group glomerular nonselective proteinuria and mixed proteinuria were diagnosed in 36.4% and 18.1% of children, respectively. In the majority of children with isolated proteinuria (66,7%) nonselective pattern was revealed. In this group glomerular selective proteinuria and mixed proteinuria were observed in 13.3% and 20% of children, respectively.

摘要

本研究的目的是评估不同肾脏疾病患儿蛋白尿的电泳模式。该研究纳入了52名年龄在2至18岁之间的患儿（30名男孩和22名女孩），他们均在卢布林大学儿童医院肾病科住院。分别有26名、11名和15名患儿被诊断为肾病综合征、肾小球肾炎和孤立性蛋白尿。使用SEBIA - Hydragel Proteinuria系统进行尿蛋白电泳。激素反应型、激素抵抗型和激素依赖型肾病综合征患儿中，分别有76%、40%和12.5%表现为肾小球选择性蛋白尿。在其他肾病患儿中，发现为肾小球非选择性蛋白尿。在45.5%的肾小球肾炎患儿中发现了选择性肾小球蛋白尿。在该组中，分别有36.4%和18.1%的患儿被诊断为肾小球非选择性蛋白尿和混合性蛋白尿。在大多数孤立性蛋白尿患儿（66.7%）中呈现非选择性模式。在该组中，分别有13.3%和20%的患儿观察到肾小球选择性蛋白尿和混合性蛋白尿。