Walker C, Gray B N, Barnard R
Dis Colon Rectum. 1981 Apr;24(3):171-5. doi: 10.1007/BF02962327.
The profile of serum glycoproteins is altered in malignancy with a relative increase in acute phase reactant proteins. A prospective study has been performed to investigate three sugar moieties (hexose, hexosamine and sialic acid) of these glycoproteins in the serum of large-bowel cancer patients as a possible guide to recurrence, and to compare these three variables with carcinoembryonic antigen (CEA). The three variables indicated the presence of colorectal cancer in over 65 per cent of 107 cancer-bearing subjects. Furthermore, the appearance of metastatic disease was associated with abnormalities in these variables in 10 of 11 patients, and appears more accurately reflected than with CEA. However, the three variables and CEA are cumulative in their value for predicting recurrent cancer. Monitoring of acute phase reactant proteins may therefore be of potential clinical benefit for monitoring of colorectal cancer patients at high risk of recurrence.
恶性肿瘤患者血清糖蛋白谱会发生改变，急性期反应蛋白相对增加。已开展一项前瞻性研究，以调查大肠癌患者血清中这些糖蛋白的三种糖基（己糖、己糖胺和唾液酸），作为复发的可能指标，并将这三个变量与癌胚抗原（CEA）进行比较。这三个变量在107名癌症患者中超过65%的病例中提示存在结直肠癌。此外，11名患者中有10名出现转移疾病与这些变量异常有关，且比CEA更能准确反映。然而，这三个变量和CEA在预测复发性癌症方面具有累积价值。因此，监测急性期反应蛋白可能对监测具有高复发风险的结直肠癌患者具有潜在的临床益处。
