Wood C B, Horne C H, Towler C M, Burt R W, Ratcliffe J G, Blumgart L H
J Clin Pathol. 1978 Nov;31(11):1065-7. doi: 10.1136/jcp.31.11.1065.
Absolute serum concentrations of pregnancy-associated alpha2-glycoprotein (alpha2-PAG) and carcinoembryonic antigen (CEA) were compared in 54 patients before and after surgery for colorectal cancer. Preoperatively, elevated levels of alpha2-PAG were found in 32 (59%) and of CEA in 35 (65%). Postoperatively, elevated alpha2-PAG levels were found in 10 of 18 patients (56%) without clinical evidence of recurrence whereas elevated CEA levels were present in three (16%). In patients who developed clinical evidence of tumour recurrence, alpha2-PAG levels were elevated in 8 of 13 (62%) while CEA levels were uniformly abnormal. It is concluded that, in this cross-sectional study, measurement of alpha2-PAG concentrations is less reliable than CEA in the detection of tumour recurrence after apparently curative surgery for colorectal cancer.
对54例接受结直肠癌手术的患者术前和术后的妊娠相关α2-糖蛋白（α2-PAG）及癌胚抗原（CEA）的血清绝对浓度进行了比较。术前，32例（59%）患者的α2-PAG水平升高，35例（65%）患者的CEA水平升高。术后，18例无临床复发证据的患者中有10例（56%）α2-PAG水平升高，而3例（16%）患者CEA水平升高。在出现肿瘤复发临床证据的患者中，13例中有8例（62%）α2-PAG水平升高，而CEA水平均异常。得出的结论是，在这项横断面研究中，对于结直肠癌根治性手术后肿瘤复发的检测，α2-PAG浓度的测量不如CEA可靠。
