Lewis N J, Inloes R L, Hes J, Matthews R H, Milo G
J Med Chem. 1978 Oct;21(10):1070-3. doi: 10.1021/jm00208a011.
The preparation of a series of synthetic sulfur-containing amino acids is described. These compounds included heterocyclic analogues of L-cysteine, DL-norcysteine, and DL-homocysteine. The amino acids were assessed for their ability to inhibit the neutral amino acid transport systems of the Sarcoma 37 ascites tumor cell and their inhibitions were compared with those of L-methionine and L-ethionine. Transport studies indicated that the amino acids synthesized were capable of inhibiting the uptake of [3H]-L-histidine in the S37 cell.
本文描述了一系列合成含硫氨基酸的制备方法。这些化合物包括L-半胱氨酸、DL-去甲半胱氨酸和DL-高半胱氨酸的杂环类似物。评估了这些氨基酸抑制肉瘤37腹水肿瘤细胞中性氨基酸转运系统的能力，并将它们的抑制作用与L-蛋氨酸和L-乙硫氨酸的抑制作用进行了比较。转运研究表明，合成的氨基酸能够抑制S37细胞对[3H]-L-组氨酸的摄取。
