Galvan G, Frick J, Irnberger T
Dtsch Med Wochenschr. 1981 May 15;106(20):637-42. doi: 10.1055/s-2008-1070370.
Conservative treatment with bromocriptine was performed in three patients with macroprolactinomas and increased prolactin levels. Lowering of prolactin levels to normal or subnormal values was possible in all cases. One extensive prolactinoma with retro- and suprasellar parts showed regression to a large extent and cystic degeneration. Transient occurrence of liquorrhoea is considered as a consequence of tumour regression. In cases of parasellar prolactinoma recurrence and intrasellar prolactinoma diminution and cystic degeneration were observed while on bromocriptine treatment. Bromocriptine dosage varied between 3.75 and 30 mg/d. Treatment was performed between 20 and 26 months. There were no serious side effects. Bromocriptine treatment offers an alternative to surgery in macroprolactinomas and prolactinoma recurrences.
对3例大泌乳素瘤且泌乳素水平升高的患者进行了溴隐亭保守治疗。所有病例中泌乳素水平均有可能降至正常或低于正常水平。1例累及鞍后和鞍上部分的巨大泌乳素瘤出现了很大程度的退缩和囊性变。脑脊液漏的短暂出现被认为是肿瘤退缩的结果。在溴隐亭治疗期间，观察到鞍旁泌乳素瘤复发、鞍内泌乳素瘤缩小及囊性变的情况。溴隐亭剂量在3.75至30mg/d之间。治疗持续了20至26个月。未出现严重副作用。溴隐亭治疗为大泌乳素瘤及泌乳素瘤复发提供了一种手术替代方案。
