某些9H-呫吨-9-酮-2-羧酸的抗过敏活性。
Antiallergic activity of some 9H-xanthen-9-one-2-carboxylic acids.
作者信息
Bristol J A, Alekel R, Fukunaga J Y, Steinman M
出版信息
J Med Chem. 1978 Dec;21(12):1327-30. doi: 10.1021/jm00210a034.
PMID:722745
Abstract
The synthesis and antiallergic activity of a new series of 9H-xanthen-9-one-2-carboxylic acids are described. Antiallergic activity was evaluated in the rat passive cutaneous anaphylaxis (PCA) screen. Biological results were analyzed using regression analysis techniques, and the antiallergic activity of the compounds in the series was found to be highly correlated with substituent size.
摘要
描述了一系列新型9H-呫吨-9-酮-2-羧酸的合成及其抗过敏活性。在大鼠被动皮肤过敏反应（PCA）试验中评估了抗过敏活性。使用回归分析技术对生物学结果进行分析，发现该系列化合物的抗过敏活性与取代基大小高度相关。
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