一些单取代和二取代呫吨-2-羧酸的合成及其抗过敏活性
Synthesis and antiallergic activity of some mono- and disubstituted xanthone-2-carboxylic acids.
作者信息
Pfister J R, Ferraresi R W, Harrison I T, Rooks W H, Fried J H
出版信息
J Med Chem. 1978 Jul;21(7):669-72. doi: 10.1021/jm00205a014.
PMID:671465
Abstract
A series of xanthone-2-carboxylic acids, substituted mainly with electron-withdrawing groups, has been synthesized and assayed for antiallergic activity, using the passive cutaneous anaphylaxis (PCA) reaction in the rat. The effect of substituent type and substitution pattern on PCA neutralizing capacity is presented.
摘要
已合成了一系列主要被吸电子基团取代的呫吨酮-2-羧酸，并利用大鼠被动皮肤过敏反应（PCA）对其抗过敏活性进行了测定。文中介绍了取代基类型和取代模式对PCA中和能力的影响。
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