Casinovi C G, Fardella G, Grandolini G, Burinato C
Farmaco Sci. 1981 Feb;36(2):116-22.
Owing to its high toxicity, ailanthone, one of the most potent in vivo amoebicidal drugs of natural origin, cannot be safely employed in clinical trials. With the aim of obtaining a compound with a better therapeutic index and of studying possible relationships between biological activity and chemical structure, many derivatives of ailanthone and of the chemically related, although biologically inactive, quassin have been prepared and tested.
由于其高毒性，臭椿酮作为最有效的天然来源体内杀阿米巴药物之一，无法在临床试验中安全使用。为了获得一种具有更好治疗指数的化合物，并研究生物活性与化学结构之间的可能关系，人们已经制备并测试了臭椿酮的许多衍生物以及化学相关但无生物活性物质苦木素的衍生物。
