Gillin F D, Reiner D S, Suffness M
Antimicrob Agents Chemother. 1982 Aug;22(2):342-5. doi: 10.1128/AAC.22.2.342.
Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.
从一种用于治疗痢疾的埃塞俄比亚植物中提纯得到的布鲁斯胺,在体外可杀死溶组织内阿米巴(半数抑制浓度[使菌落数量降至对照一半的药物浓度]=0.018微克/毫升)。所测试的17种相关苦木素类化合物中的6种也具有杀阿米巴作用。苦木素类化合物的结构与杀阿米巴活性之间没有明显关联。