Weiner H
Fed Proc. 1981 May 15;40(7):2082-5.
Dopamine-derived tetrahydroisoquinolines such as salsolinol and tetrahydropapaveroline have been implicated in alcohol-related problems. Though their infusion into the brain can induce a rat to increase its alcohol consumption, it is not known whether the compounds actually form in vivo. Few investigators have been able to extract the compounds or their metabolites from tissue or urine. One notable exception is reported by Collins et al. (Science 206: 1184--1186; 1979), who found that alcoholics excrete 140 micrograms/24 h of O-methyl salsolinol and salsolinol. Using that value as the rate of salsolinol formation in brain, it was possible to estimate the steady-state concentration that could be expected to be found in brain. It was assumed that the rate of synthesis is equal to the rate of removal from tissue. Thus, the concentration is simply vf/kd, where vf is the rate of formation and kd is the rate constant for the disappearance from brain. It is necessary to estimate the concentration of dopamine and aldehyde in brain to determine the rate of formation. The realistic upper limits for salsolinol and tetrahydropapaveroline in brain are ca. 1 ng/g brain tissue. These values are below the level of detection commonly employed.
多巴胺衍生的四氢异喹啉类物质，如萨索林醇和四氢罂粟碱，与酒精相关问题有关。尽管将它们注入大脑会促使大鼠增加酒精摄入量，但尚不清楚这些化合物在体内是否真的会形成。很少有研究人员能够从组织或尿液中提取出这些化合物或其代谢产物。柯林斯等人（《科学》206：1184 - 1186；1979年）报告了一个显著的例外情况，他们发现酗酒者每24小时排出140微克的O - 甲基萨索林醇和萨索林醇。以该值作为大脑中萨索林醇的形成速率，就有可能估算出大脑中预期会发现的稳态浓度。假设合成速率等于从组织中清除的速率。因此，浓度简单地为vf/kd，其中vf是形成速率，kd是从大脑中消失的速率常数。有必要估算大脑中多巴胺和醛的浓度以确定形成速率。大脑中萨索林醇和四氢罂粟碱的实际上限约为每克脑组织1纳克。这些值低于常用的检测水平。
