Takahashi T, Tani M, Shimazu H
Gastroenterol Jpn. 1981;16(1):71-5. doi: 10.1007/BF02820427.
Tissue and serum immunoreactive gastrin (IRG) concentrations were measured by radioimmunoassay, and antral G cell density was studied by immunofluorescence in seven non-operative and ten vagotomized (one month postoperatively) rats. In the non-operative rats, tissue IRG concentration was overwhelmingly high in the antrum, especially in the distal antrum, and much less in the small intestine, in which it tended to be lower toward the distal part. There were no significant differences between the vagotomized and non-operative rats in antral G cell density, antral tissue IRG concentration, total IRG content of the anterior antrum and serum IRG level, although significantly increased wet weight of the specimen, which was considered a result of the operation, was observed in vagotomized rats. The presence of G cell hyperplasia after vagotomy cannot be confirmed from our one-month postoperative observations in rats.
采用放射免疫分析法测定了7只未做手术和10只迷走神经切断术（术后1个月）大鼠的组织和血清免疫反应性胃泌素（IRG）浓度，并通过免疫荧光法研究了胃窦G细胞密度。在未做手术的大鼠中，组织IRG浓度在胃窦中极高，尤其是在胃窦远端，而在小肠中则少得多，且在小肠中越靠近远端浓度越低。迷走神经切断术大鼠与未做手术的大鼠在胃窦G细胞密度、胃窦组织IRG浓度、胃窦前部总IRG含量和血清IRG水平方面无显著差异，尽管在迷走神经切断术大鼠中观察到标本湿重显著增加，这被认为是手术的结果。从我们对大鼠术后1个月的观察结果来看，无法证实迷走神经切断术后存在G细胞增生。
