Delince P, Willems G, de Graef J
Digestion. 1978;18(1-2):27-34. doi: 10.1159/000198181.
The total number of antral gastrin cells, the antral surface area and the serum gastrin concentration were determined in two groups of rats. The animals had been submitted at random either to vagotomy and pyloroplasty or to pyloroplasty alone 3 weeks before. The indirect immunoperoxidase reaction and a direct quantitative histological method were used to count the gastrin cells. Radioimmunoassay was used to estimate the serum gastrin concentration. The total number of gastrin cells in the stomach was 52% (p less than 0.01) more elevated in the vagotomized animals. Both antral mucosal surface and calculated concentration of gastrin cells per square millimeter of mucosa were significantly higher (0.01 less than p less than 0.05) in this group of animals. The serum gastrin values were significantly (p less than 0.01) more elevated after vagotomy. These observations indicate that vagotomy may induce an antral gastrin cell hyperplasia which could explain in part the hypergastrinemia observed after this surgical procedure.
在两组大鼠中测定了胃窦部胃泌素细胞总数、胃窦表面积和血清胃泌素浓度。这些动物在3周前被随机分为两组，一组接受迷走神经切断术和幽门成形术，另一组仅接受幽门成形术。采用间接免疫过氧化物酶反应和直接定量组织学方法对胃泌素细胞进行计数。采用放射免疫分析法测定血清胃泌素浓度。迷走神经切断术后，胃中胃泌素细胞总数升高了52%（p<0.01）。该组动物的胃窦黏膜表面积和每平方毫米黏膜计算的胃泌素细胞浓度均显著更高（0.01<p<0.05）。迷走神经切断术后血清胃泌素值显著升高（p<0.01）。这些观察结果表明，迷走神经切断术可能会诱导胃窦部胃泌素细胞增生，这可能部分解释了该手术后观察到的高胃泌素血症。
