Ponz de Leon M, Loria P, Iori R, Carulli N
Gastroenterology. 1981 Jun;80(6):1428-37.
Dietary cholesterol absorption was studied in patients with either "mild" (n = 23) or "severe" (n = 12) liver cirrhosis in relation to both total and individual bile acid pool size. Cholesterol absorption was significantly reduced in both groups of patients, and it was inversely related (r = -0.68; p less than 0.001) to the severity of the disease. Total, cholic acid, and deoxycholic acid p ool sizes were significantly reduced in cirrhosis, and a correlation was found between cholesterol absorption and cholic acid pool size (r = 0.78; p less than 0.001). In 5 patients, cholesterol absorption and bile acid pool size were estimated both before and after treatment with cholic acid (15 mg/kg/day) plus ampicillin (2 g/day). The treatment was followed by a mean threefold increase of cholic acid pool and by a sharp enhancement of cholesterol absorption in each patient. In conclusion, cholesterol absorption is often impaired in cirrhosis and is related to the severity of the disease. The correlation between cholic acid pool and cholesterol absorption and the constant increase of the absorption values after cholic acid pool expansion suggest that the size of cholic acid pool may be considered as an important factor in the regulation of cholesterol absorption.
对“轻度”（n = 23）或“重度”（n = 12）肝硬化患者的膳食胆固醇吸收情况进行了研究，研究内容涉及总胆汁酸池大小和个体胆汁酸池大小。两组患者的胆固醇吸收均显著降低，且与疾病严重程度呈负相关（r = -0.68；p < 0.001）。肝硬化患者的总胆汁酸、胆酸和脱氧胆酸池大小均显著减小，且发现胆固醇吸收与胆酸池大小之间存在相关性（r = 0.78；p < 0.001）。对5例患者在使用胆酸（15 mg/kg/天）加氨苄西林（2 g/天）治疗前后分别评估了胆固醇吸收和胆汁酸池大小。治疗后，每位患者的胆酸池平均增加了三倍，胆固醇吸收也急剧增强。总之，肝硬化患者的胆固醇吸收常受损，且与疾病严重程度相关。胆酸池与胆固醇吸收之间的相关性以及胆酸池扩大后吸收值的持续增加表明，胆酸池大小可能被视为调节胆固醇吸收的一个重要因素。
