Demenais F M, Elston R C
Hum Hered. 1981;31(2):93-9. doi: 10.1159/000153185.
The three basic transmission probabilities of the two-allele autosomal genetic model proposed by Elston and Stewart in 1971 are made dependent on sex. It is shown that this more general model, comprising twelve transmission probabilities, subsumes the most important simple modes of genetically or environmentally determined transmission that may be responsible for the familial aggregation of traits. Although this does not necessarily solve the problem of testing alternative hypotheses, it provides a holistic parametrization of familial transmission.
1971年埃尔斯顿和斯图尔特提出的双等位基因常染色体遗传模型的三个基本传递概率取决于性别。结果表明,这个包含十二个传递概率的更通用模型涵盖了可能导致性状家族聚集的遗传或环境决定的传递的最重要简单模式。虽然这不一定能解决检验替代假设的问题,但它提供了家族传递的整体参数化。