Kim Y K, Tannenbaum S R, Wishnok J S
IARC Sci Publ. 1980(31):207-14.
The rate of nitrosation of dihexylamine is enhanced when the reaction is carried ut in the presence of micelles containing bile acid conjugates or bile acid conjugates and lecithin. The nitrosation of smaller dialkylamines is not affected. The nitrosation of dihexylamine under these conditions is inhibited by alpha-tocopherol at pH 3 or pH 5. At pH 3 the reaction is inhibited by ascorbic acid, while at pH 5 it is inhibited by equimolar concentrations of ascorbic acid, but accelerated by higher concentration of ascorbic acid. The effect of ascorbic acid at pH 5 depends on the presence of oxygen and sulfamate.
当反应在含有胆汁酸共轭物或胆汁酸共轭物与卵磷脂的胶束存在下进行时，二己胺的亚硝化速率会提高。较小的二烷基胺的亚硝化不受影响。在这些条件下，α-生育酚在pH 3或pH 5时会抑制二己胺的亚硝化。在pH 3时，抗坏血酸会抑制该反应，而在pH 5时，等摩尔浓度的抗坏血酸会抑制该反应，但较高浓度的抗坏血酸会加速该反应。抗坏血酸在pH 5时的作用取决于氧气和氨基磺酸盐的存在。
