Ehrlichman R J, Isaacs J T, Coffey D S
Invest Urol. 1981 May;18(8):466-70.
The treatment of castrate beagles with a combination of estradiol an dihydrotestosterone (DHT) results in the synergistic enhancement of prostatic growth and the experimental induction of benign prostatic hyperplasia. This estradiol synergism can be shown as a greater than 3 fold increase in both prostatic wet weight and total DNA content in castrate dogs treated with both steroids, as compared to those animals treated with DHT alone. In direct contrast to the situation in the dog, there was no evidence of estradiol synergism on prostatic growth when castrate rats were treated with combinations of estradiol and DHT, even if both the ratio and absolute amount of both steroids were experimentally varied over a wide range of values. Regardless of the ratio or absolute dose, estradiol was completely unable to synergize the DHT induced growth of the prostate as well as other sex accessory tissues of the castrate rat. This indicates a fundamental difference between the rat and dog in regard to prostatic growth response to combinations of estradiol and DHT treatment.
用雌二醇和双氢睾酮（DHT）联合治疗去势比格犬，可协同促进前列腺生长并实验性诱导良性前列腺增生。与仅用DHT治疗的动物相比，在用两种类固醇治疗的去势犬中，这种雌二醇协同作用可表现为前列腺湿重和总DNA含量均增加超过3倍。与犬的情况形成直接对比的是，当用雌二醇和DHT联合治疗去势大鼠时，即使两种类固醇的比例和绝对量在很宽的实验值范围内变化，也没有证据表明雌二醇对前列腺生长有协同作用。无论比例或绝对剂量如何，雌二醇完全无法协同DHT诱导去势大鼠前列腺以及其他性附属组织的生长。这表明大鼠和犬在对雌二醇和DHT联合治疗的前列腺生长反应方面存在根本差异。
