Walvoord D J, Resnick M I, Grayhack J T
Invest Urol. 1976 Jul;14(1):60-5.
This study has been designed to investigate possible potentiation of testosterone and dihydrotestosterone by estradiol and prolactin in augmenting weight and citric acid content of the rat lateral prostate. Using these parameters, we hoped to indirectly assess the effect of estradiol and prolactin on 5alpha-reduction as it acts on the conversion of testosterone to dihydrotesterone. In the first part of the study, 87 castrate and 14 control rats were used to assess the effect of testosterone or dihydrotestosterone when supplemented with estradiol; in the second part of the study, 121 castrate-hypophysectomized rats separated into three groups according to age and stage of maturation were used to assess the effect of prolactin in supplementing testosterone and dihydrotestosterone. Estradiol appears to have a greater effect on 5alpha-reduction than does prolactin; however, other pathways of androgen metabolism are altered by these agents. These alternate pathways are discussed.
本研究旨在探究雌二醇和催乳素对睾酮和双氢睾酮的潜在增强作用，这种增强作用体现在增加大鼠前列腺外侧的重量和柠檬酸含量方面。利用这些参数，我们希望间接评估雌二醇和催乳素对5α-还原的影响，因为它作用于睾酮向双氢睾酮的转化过程。在研究的第一部分，使用87只去势大鼠和14只对照大鼠来评估补充雌二醇时睾酮或双氢睾酮的作用；在研究的第二部分，将121只去势并切除垂体的大鼠根据年龄和成熟阶段分为三组，用于评估催乳素对补充睾酮和双氢睾酮的作用。雌二醇似乎比催乳素对5α-还原的影响更大；然而，这些药物会改变雄激素代谢的其他途径。文中对这些替代途径进行了讨论。
