清醒志愿者体内芬太尼的药代动力学
Fentanyl pharmacokinetics in awake volunteers.
作者信息
Fung D L, Eisele J H
出版信息
J Clin Pharmacol. 1980 Nov-Dec;20(11):652-8. doi: 10.1002/j.1552-4604.1980.tb01682.x.
Abstract
A single intravenous dose of fentanyl (either 2 or 4 micrograms/kg body weight) was given to 13 healthy, young volunteer subjects. Serum fentanyl concentration decreased in a triexponential pattern. The terminal half-times were 750 and 853 minutes, respectively. A three-compartment, open, mammillary model is proposed for fentanyl kinetics.
摘要
给13名健康的年轻志愿者单次静脉注射芬太尼（2或4微克/千克体重）。血清芬太尼浓度呈三室指数下降模式。终末半衰期分别为750分钟和853分钟。提出了一个三室开放乳头模型用于芬太尼动力学研究。
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