Wang R I, Johnson R P, Robinson N, Waite E
J Clin Pharmacol. 1981 Feb-Mar;21(2):121-5. doi: 10.1002/j.1552-4604.1981.tb01761.x.
The efficacy and safety of 0.3 mg buprenorphine on single and repeated intramuscular administration (every 4 to 8 hours as needed) were compared to those of 10 mg intramuscular morphine. Fifty adult patients experiencing moderate to severe postoperative pain were evaluated up to three days following surgery. Results showed that 0.3 mg buprenorphine was as effective as 10 mg morphine, whether given as a single dose or on a repeat-dose schedule. The patterns of analgesia were similar and without indication of increasing dosage requirements with time. Minor side effects encountered were brief and minimal, including such conditions as drowsiness, dizziness, diaphoresis, flushing, and nausea.
将0.3毫克丁丙诺啡单次及重复肌内注射（按需每4至8小时一次）的疗效和安全性与10毫克肌内注射吗啡进行了比较。对50名成年术后中重度疼痛患者进行了术后三天的评估。结果显示，无论是单次给药还是重复给药，0.3毫克丁丙诺啡与10毫克吗啡的效果相同。镇痛模式相似，且没有随着时间推移而增加剂量需求的迹象。出现的轻微副作用短暂且轻微，包括嗜睡、头晕、发汗、脸红和恶心等情况。
