Vanacker B, Vandermeersch E, Tomassen J
Curr Med Res Opin. 1986;10(2):139-44. doi: 10.1185/03007998609110432.
The analgesic efficacy and tolerance of a single intramuscular injection of either buprenorphine (0.3 mg) or a buprenorphine (0.3 mg)/naloxone (0.2 mg) combination was compared in 70 patients suffering from moderate to severe pain after abdominal surgery. Patients in both treatment groups experienced good analgesia which was apparent within 10 minutes of administration and lasted for approximately 12 hours. The most frequently reported unwanted effects were drowsiness and/or sleepiness and nausea and/or vomiting which were of mild or moderate severity in most cases. No significant differences were seen between the two treatment groups with regard to the overall assessments of efficacy and tolerance.
对70例腹部手术后中重度疼痛患者比较了单次肌内注射布托啡诺（0.3毫克）或布托啡诺（0.3毫克）/纳洛酮（0.2毫克）组合的镇痛效果及耐受性。两个治疗组的患者均获得了良好的镇痛效果，给药后10分钟内即显效，持续约12小时。最常报告的不良反应为嗜睡和/或困倦以及恶心和/或呕吐，多数情况下为轻度或中度。在疗效和耐受性的总体评估方面，两个治疗组之间未见显著差异。
