Grund V R, Hunninghake D B
J Clin Pharmacol. 1981 Feb-Mar;21(2):87-91. doi: 10.1002/j.1552-4604.1981.tb01755.x.
The influence of an H2-histamine receptor antagonist, cimetidine, on histamine-induced changes in heart rate and blood pressure was examined in a randomized double-blind study in six fasted male subjects. The intravenous infusion of histamine (10 microgram/min) for 20 minutes caused an immediate and sustained increase in heart rate (26 per cent and a transient fall in mean arterial blood pressure (10 per cent). Cimetidine pretreatment (300 mg intravenously) inhibited histamine-elevated heart rate by 75 per cent (P less than 0.05) and histamine-decreased blood pressure by 54 per cent (P less than 0.05). Cimetidine by itself did not cause significant changes in heart rate or blood pressure. These results illustrate that H2-histamine receptor antagonists significantly inhibit histamine-induced increases in heart rate in man and support the potential use of cimetidine in certain cases of tachyarrhythmia.
在一项针对6名禁食男性受试者的随机双盲研究中，研究了H2组胺受体拮抗剂西咪替丁对组胺引起的心率和血压变化的影响。静脉输注组胺（10微克/分钟）20分钟导致心率立即持续增加（26%），平均动脉血压短暂下降（10%）。西咪替丁预处理（静脉注射300毫克）可使组胺引起的心率升高抑制75%（P<0.05），使组胺引起的血压下降抑制54%（P<0.05）。西咪替丁本身不会引起心率或血压的显著变化。这些结果表明，H2组胺受体拮抗剂可显著抑制人体组胺引起的心率升高，并支持西咪替丁在某些快速性心律失常病例中的潜在应用。
