Baker L J, Kesner R P, Michal R E
J Comp Physiol Psychol. 1981 Apr;95(2):312-21. doi: 10.1037/h0077773.
The present study examined the effects of a footshock reminder in restoring memory after discrete electrical brain stimulation. Rats received low-level bilateral electrical stimulation of either the amygdala or the hippocampus after training in a one-trial passive avoidance task. Rats receiving stimulation showed amnesia when tested 24 hr after training. One hour after the retention test, rats received a footshock reminder cue. Twenty-three hours later, in a second retention test, hippocampus-stimulated animals showed recovery of memory, while amygdala-stimulated rats did not. Stimulated rats that did not receive a reminder footshock remained amnesic. In addition, the effects of amygdala and hippocampal stimulation applied after the footshock reminder cue were examined. On the second retention test, amygdala stimulation disrupted the reminder effect, while hippocampal stimulation had no deleterious effects. The data are interpreted from a memory-attribute point of view which suggests that the amygdala and hippocampus may be differentially involved in the processing of particular attributes of the learning task.
本研究考察了足部电击提示在离散性脑电刺激后恢复记忆方面的作用。大鼠在单次被动回避任务训练后，接受了杏仁核或海马体的低水平双侧电刺激。接受刺激的大鼠在训练后24小时进行测试时表现出失忆。在记忆保持测试1小时后，大鼠接受了足部电击提示线索。23小时后，在第二次记忆保持测试中，海马体刺激组的动物表现出记忆恢复，而杏仁核刺激组的大鼠则没有。未接受提示性足部电击的受刺激大鼠仍处于失忆状态。此外，还研究了在足部电击提示线索后施加杏仁核和海马体刺激的效果。在第二次记忆保持测试中，杏仁核刺激破坏了提示效果，而海马体刺激没有产生有害影响。这些数据是从记忆属性的角度进行解释的，这表明杏仁核和海马体可能在学习任务的特定属性处理中发挥不同的作用。
