雄性和雌性F344大鼠外周器官中儿茶酚胺含量的年龄相关变化。

Age-related changes in the catecholamine content of peripheral organs in male and female F344 rats.

作者信息

Martinez J L, Vasquez B J, Messing R B, Jensen R A, Liang K C, McGaugh J L

出版信息

J Gerontol. 1981 May;36(3):280-4. doi: 10.1093/geronj/36.3.280.

DOI:10.1093/geronj/36.3.280

Abstract

Norepinephrine levels of old and young F344 rats of both sexes were compared in several organs that receive sympathetic innervation. In addition, both norepinephrine and epinephrine concentrations in the adrenal medulla of young and old rats were determined. A rationale was developed for making age-related comparisons of the catecholamine content in peripheral organs which accounted for age-related changes in organ weight and body weight. It was found that norepinephrine concentrations were decreased for old male rats in heart auricles. In contrast, in old female rats there were no age-related changes in the catecholamine content of any peripheral organ.

摘要

对接受交感神经支配的多个器官中雄性和雌性老年及幼年F344大鼠的去甲肾上腺素水平进行了比较。此外，还测定了幼年和老年大鼠肾上腺髓质中去甲肾上腺素和肾上腺素的浓度。建立了一个理论依据，用于对周围器官中儿茶酚胺含量进行与年龄相关的比较，该依据考虑了器官重量和体重的年龄相关变化。结果发现，老年雄性大鼠心耳中的去甲肾上腺素浓度降低。相比之下，老年雌性大鼠任何周围器官中的儿茶酚胺含量均未出现与年龄相关的变化。