Chujo T
Jpn J Physiol. 1978;28(4):433-45. doi: 10.2170/jjphysiol.28.433.
Experiments were done to elucidate properties of the late N-wave which was induced in vitro in thin sections of the olfactory cortex of the rat in response to stimulation of the lateral olfactory tract. The late N-wave decreased in size at a stimulation rate of more than once every 90 sec or at temperatures higher than 27 degrees C. The late N-wave was suppressed in the presence of GABA, picrotoxin or bicuculline or in the Cl-free medium. Penicillin or pentylenetetrazol, which blocked actions of GABA on the presynaptic potential, also suppressed the late N-wave. The late N-wave first appeared at postnatal ages of 18--25 days. The late N-wave reversed in polarity when recorded from the deep layers of the sections or from the cut surface of the sections. Single cells in the deep portions of the sections discharged during the late N-wave. Cells in the superficial layers fired just before or after the late N-wave. In order to explain these observations, a neuronal model for generation of the late N-wave was presented.
进行了实验以阐明大鼠嗅皮质薄片在体外因外侧嗅束刺激而诱发的晚期N波的特性。当刺激频率超过每90秒一次或温度高于27摄氏度时，晚期N波的大小减小。在存在GABA、苦味毒或荷包牡丹碱的情况下或在无氯培养基中，晚期N波受到抑制。阻断GABA对突触前电位作用的青霉素或戊四氮也抑制晚期N波。晚期N波在出生后18 - 25天首次出现。当从薄片的深层或薄片的切割表面记录时，晚期N波的极性反转。薄片深部的单个细胞在晚期N波期间放电。表层细胞在晚期N波之前或之后放电。为了解释这些观察结果，提出了一个产生晚期N波的神经元模型。
