大鼠嗅觉皮层中可能存在的突触前抑制。
Possible presynaptic inhibition in rat olfactory cortex.
作者信息
Pickles H G, Simmonds M A
出版信息
J Physiol. 1976 Sep;260(2):475-86. doi: 10.1113/jphysiol.1976.sp011526.
Abstract
- Field potentials were evoked from rat olfactory cortex slices in vitro at room temperature by lateral olfactory tract stimulation. At very slow stimulation rates (less than 0-1 Hz) a delayed negative wave (late N-wave) was found to follow the first negative wave (N-wave). This late N-wave started 30 msec after the stimulus and lasted for 50-150 msec. 2. Low Ca2+/high Mg2+ medium abolished the late N-wave more rapidly than the N-wave, suggesting a possible multisynaptic origin. 3. The GABA antagonist bicuculline (10(-6) M) abolished the late N-wave without affecting the N-wave. 4. During the late N-wave, both the tract action potential and the N-wave to a second stimulus were reduced. This was attributed, at least in part, to collision with antidromic action potentials which could be detected during the late N-wave. 5. These findings are discussed in terms of a possible presynaptic depolarizing action of a GABA-like transmitter giving rise to presynaptic inhibition and the late N-wave.
摘要
- 在室温下，通过刺激大鼠离体嗅皮质切片的外侧嗅束诱发场电位。在非常缓慢的刺激频率（低于0.1赫兹）下，发现一个延迟负波（晚期N波）跟随第一个负波（N波）出现。这个晚期N波在刺激后30毫秒开始，持续50 - 150毫秒。2. 低钙/高镁培养基比N波更快地消除了晚期N波，提示其可能起源于多突触。3. GABA拮抗剂荷包牡丹碱（10⁻⁶M）消除了晚期N波，而不影响N波。4. 在晚期N波期间，束动作电位和对第二个刺激的N波都降低了。这至少部分归因于与在晚期N波期间可检测到的逆行动作电位的碰撞。5. 根据一种类似GABA的递质可能产生突触前去极化作用从而引起突触前抑制和晚期N波这一观点，对这些发现进行了讨论。
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