Castellano T, Medwick T, Shinkai J H, Bailey L
J Pharm Sci. 1981 Jan;70(1):104-5. doi: 10.1002/jps.2600700126.
A study of bases in acetic acid and their differential titration was carried out. The overall basicity constants for 20 bases were measured in acetic acid, and the differential titration of five binary mixtures of variable delta pKb values in acetic acid was followed using a glass electrode-modified calomel electrode system. Agreement with literature values was good. A leveling diagram was constructed that indicated that bases stronger than aqueous pKb 10 are leveled to an acetous pKb 5.69, whereas weaker bases are not leveled but instead exhibit their own intrinsic basicity, with the acetous pKb to aqueous pKb values being linearly related (slope 1.18, correlation coefficient 0.962). A minimum acetous delta pKb of four units is required for the satisfactory differential titration of two bases in acetic acid.
开展了一项关于乙酸中碱及其微分滴定的研究。测定了20种碱在乙酸中的总碱度常数，并使用玻璃电极 - 改良甘汞电极系统跟踪了乙酸中五种具有可变ΔpKb值的二元混合物的微分滴定。与文献值吻合良好。构建了一个分级图，表明碱性强于水溶液pKb 10的碱被分级为乙酸pKb 5.69，而较弱的碱则不被分级，而是表现出其自身的固有碱性，乙酸pKb与水溶液pKb值呈线性关系（斜率1.18，相关系数0.962）。乙酸中两种碱进行满意的微分滴定需要最小乙酸ΔpKb为四个单位。
