Amirjahed K, al-Khamis K I
J Pharm Sci. 1980 Oct;69(10):1151-4. doi: 10.1002/jps.2600691007.
The benzene-acetonitrile binary solvent system was used in the determination of the half-neutralization potentials (hnp) of selected bases varying widely in basicity (pKb). The solvent mixtures had specific dielectric constants (Dm). The hnp values of the bases determined in a solvent of a specific Dm value were related to the corresponding pKb values. The slopes of these linear relationships were related to Dm values. A certain mixture of the binary solvent system was selected, and successful differentiating titration of various base mixtures was demonstrated in this medium. The delta hnp/delta pK versus Dm data for acids were compared with those of bases in the benzene-acetonitrile binary solvent system. The resulting data on bases were compared with previously published data on acids, and the present report describes the behavior of acids and bases in the entire composition spectrum of the benzene-acetonitrile binary solvent system.
苯 - 乙腈二元溶剂体系用于测定碱性（pKb）差异很大的选定碱的半中和电位（hnp）。溶剂混合物具有特定的介电常数（Dm）。在特定Dm值的溶剂中测定的碱的hnp值与相应的pKb值相关。这些线性关系的斜率与Dm值相关。选择了二元溶剂体系的某种混合物，并在该介质中证明了对各种碱混合物的成功区分滴定。将苯 - 乙腈二元溶剂体系中酸的δhnp/δpK与碱的数据进行了比较。将所得的碱的数据与先前发表的酸的数据进行了比较，本报告描述了苯 - 乙腈二元溶剂体系整个组成范围内酸和碱的行为。
